5 results found
    1. Chromosomes and Gene Expression

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff, Srinivas Ramachandran ... Jorja G Henikoff
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

    Jan Wisniewski, Bassam Hajj ... Carl Wu
    Internally tagged, functional Cse4/CENP-A/CenH3 histone variant is exclusively centromeric and stable through the budding yeast cell cycle after replacement in S phase.
    1. Neuroscience

    A long non-coding RNA is required for targeting centromeric protein A to the human centromere

    Delphine Quénet, Yamini Dalal
    A non-coding RNA-based targeting mechanism could potentially epigenetically maintain specialized chromatin structures, such as the centromere, in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Decoding the centromeric nucleosome through CENP-N

    Satyakrishna Pentakota, Keda Zhou ... Karolin Luger
    A comprehensive structural, biochemical, and cell biological analysis reveals the molecular mechanism and significance of the conserved interaction of centromeric protein N (CENP-N) with the centromeric nucleosome.
    1. Biochemistry and Chemical Biology

    An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast

    Jackie Lang, Adrienne Barber, Sue Biggins
    An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.

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