78 results found
    1. Cancer Biology

    Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

    Ernesto Pérez et al.
    The oncogenic RasV12 keeps cells mutant for the tumor suppressor scribble in an undead-like condition, which is required for an amplification loop that promotes tumorigenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Spectrin binding motifs regulate Scribble cortical dynamics and polarity function

    Batiste Boëda, Sandrine Etienne-Manneville
    A new protein–protein interaction motif identified in the polarity protein and tumor suppressor Scribble, and other cortical proteins, controls their interaction with spectrins and is crucial for the localization and function of Scribble.
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez et al.
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Neuroscience

    Specific lexico-semantic predictions are associated with unique spatial and temporal patterns of neural activity

    Lin Wang et al.
    The prediction of specific words is associated with distinct spatial and temporal patterns of neural activity within the left inferior and medial temporal regions before the predicted word is presented.
    1. Cell Biology

    Scaffold-mediated gating of Cdc42 signalling flux

    Péter Rapali et al.
    The scaffold Bem1 increases the rate of GEF-mediated Cdc42 activation, while also increasing the rate and extent of GEF phosphorylation by PAK, which attenuates further scaffold stimulation.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction

    Rebeccah J Katzenberger et al.
    Use of a newly developed experimental model in fruit flies reveals that death following traumatic brain injury is largely due to a mechanism by which brain damage triggers disruption of the intestinal barrier, leading to elevated levels of glucose in the circulatory system with deleterious consequences.
    1. Developmental Biology

    A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

    Joana Torres et al.
    A previously unknown oncogenic feature of an embryonic transcription factor was uncovered from transcriptomic analysis of tumors that lack functional Polycomb silencing.
    1. Ecology
    2. Evolutionary Biology

    Heart fossilization is possible and informs the evolution of cardiac outflow tract in vertebrates

    Lara Maldanis et al.
    The discovery of a fossil heart in Rhacolepis buccalis demonstrates that it is possible to scrutinize the fossil record for important clues on cardiac structure and evolution.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deep generative models for T cell receptor protein sequences

    Kristian Davidsen et al.
    Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.

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