19 results found
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote et al.
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Cell Biology

    TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

    António JM Santos et al.
    Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.
    1. Structural Biology and Molecular Biophysics

    Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

    Yoshinori Hirano et al.
    The C2-domain of cytoplasmic phospholipase A2α is structurally designed to target PC-rich membrane regions to increase the enzymatic efficiency of the catalytic domain, which prefers PCs with polyunsaturated acyl chains.
    1. Cell Biology

    A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

    Alberto T Gatta et al.
    A new family of sterol-specific lipid transfer proteins has been found that anchors in the endoplasmic reticulum; some of these proteins stretch across membrane contacts and mediate sterol traffic from the plasma membrane.
    1. Cell Biology

    In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

    Angelica Aguilera-Gomez et al.
    Amino-acid induced Sec body formation is mediated by PARP16 dependent MARylation of Sec16, a component of the endoplasmic reticulum exit site.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Cancer Biology
    2. Computational and Systems Biology

    Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate

    Malene Juul et al.
    A new statistical approach identifies non-coding regulatory regions of genes as driver candidates with recurrent mutations across cancer samples that associate with gene expression, patient survival or mutational phenotype.
    1. Cell Biology

    Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

    Gareth Bloomfield et al.
    Inactivation of the Dictyostelium orthologue of the tumour suppressor Neurofibromin (NF1) enables amoebae to ingest dissolved nutrients using macropinocytosis more rapidly, and to prey on larger organisms using phagocytosis.
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni et al.
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.

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