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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A functional link between the co-translational protein translocation pathway and the UPR

    Rachel Plumb et al.
    Ire1α co-opts the Sec61 translocon channel to efficiently cleave its mRNA substrates during endoplasmic reticulum stress conditions.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mutational analysis of the ribosome-arresting human XBP1u

    Vivekanandan Shanmuganathan et al.
    Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it stronger.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang et al.
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The architecture of EMC reveals a path for membrane protein insertion

    John P O'Donnell et al.
    Structural and biochemical analysis of an abundant and conserved protein complex called EMC shows how it is likely to insert nascent membrane proteins into the endoplasmic reticulum membrane.
    1. Biochemistry and Chemical Biology

    Membrane Fusion: Molecular machinery turns full circle

    Josep Rizo et al.
    Two proteins called Sec17 and Sec18 may have a larger role in membrane fusion than is commonly assumed in textbook models.
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    1. Cell Biology

    In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

    Angelica Aguilera-Gomez et al.
    Amino-acid induced Sec body formation is mediated by PARP16 dependent MARylation of Sec16, a component of the endoplasmic reticulum exit site.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

    Junyi Jiao et al.
    Sec1/Munc18-family proteins chaperone SNARE assembly via a common templating mechanism.
    1. Cell Biology
    2. Developmental Biology

    The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

    Bo Gong et al.
    Sec14l3/SEC14L2 respond to upstream Wnt/Frizzled/Dvl stimulation to recruit and activate phospholipase Cδ4a (Plcδ4a) to further initiate calcium release.