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    1. Neuroscience

    Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

    Keming Zhou et al.
    The precise position of UNC-13 at the active zone near a synapse depends on the N-terminus of the protein, and the C2A domain in particular, and is essential for accelerating neurotransmitter release.
    1. Cancer Biology
    2. Cell Biology

    GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

    Jenna L Jewell et al.
    Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian target of rapamycin complex 1 (mTORC1) activity.
    1. Cell Biology
    2. Neuroscience

    Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP

    Eric A Prinslow et al.
    Biophysical analyses indicate that Munc18-1, Munc13-1, synaptotagmin-1 and complexin-1 maintain assembled trans-SNARE complexes in the presence of NSF-alphaSNAP, suggesting that they form part of the primed state of synaptic vesicles.
    1. Biochemistry and Chemical Biology

    A distinct tethering step is vital for vacuole membrane fusion

    Michael Zick, William T Wickner
    Rigorous assays of membrane fusion show that a distinct tethering step is required for lumenal compartment mixing in a manner that extends beyond simply increasing the amount of total trans-SNARE complex.
    1. Cell Biology

    A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

    Alberto T Gatta et al.
    A new family of sterol-specific lipid transfer proteins has been found that anchors in the endoplasmic reticulum; some of these proteins stretch across membrane contacts and mediate sterol traffic from the plasma membrane.
    1. Neuroscience

    Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity

    Jennifer M Ortega et al.
    Genetic and electrophysiological experiments define how homeostatic signaling stabilizes both the gain and short-term dynamic properties of neurotransmitter release, ensuring that synaptic information transfer remains robust to external perturbation.
    1. Cell Biology

    In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

    Angelica Aguilera-Gomez et al.
    Amino-acid induced Sec body formation is mediated by PARP16 dependent MARylation of Sec16, a component of the endoplasmic reticulum exit site.
    1. Cell Biology
    2. Plant Biology

    ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis

    Matthias Karnahl et al.
    SNARE proteins are delivered as complexes already from the endoplasmic reticulum along the secretory pathway to the cell division plane to mediate the formation of the partitioning membrane by vesicle fusion.
    1. Physics of Living Systems

    Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

    Lu Ma et al.
    The Munc18-1 protein promotes formation of the t-SNARE complex and the half-zippered SNARE complex, two rate-limiting steps of SNARE assembly, to enhance membrane fusion.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

    Junyi Jiao et al.
    Sec1/Munc18-family proteins chaperone SNARE assembly via a common templating mechanism.