67 results found
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway

    Brittany K Miller et al.
    SatS of Mycobacterium tuberculosis is a new protein export chaperone with a role in exporting proteins by the specialized SecA2 pathway and a role in intracellular growth in macrophages.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome

    Savita Lochab et al.
    Mycobacterium tuberculosis (Mtb), effectors secreted through SecA2 pathway cause double strand breaks (DSBs) in the host DNA, which in turn activates ATM kinase to gain survival advantages, through Akt.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

    William John Allen et al.
    Evidence is presented that supports a completely new, diffusion-driven mechanism for transporting proteins across membranes in bacteria.
    1. Structural Biology and Molecular Biophysics

    HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

    Zainab Ahdash et al.
    Hydrogen-deuterium exchange mass spectrometry reveals nucleotide-driven conformational regulation of Sec protein-channel to help impose directionality for protein transport through the Sec complex.
    1. Microbiology and Infectious Disease

    Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis

    Wenqi Yu et al.
    Surface protein precursors traffic to lipoteichoic acid-rich septal membranes of Staphylococcus aureus for cleavage of their YSIRK-GXXS motif signal peptides and SecA-mediated translocation across the plasma membrane.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

    Robin A Corey et al.
    How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
    1. Neuroscience

    A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2

    Pratap Meera et al.
    A damaging form of positive feedback linking elevated calcium levels and metabotropic glutamate receptor function in Purkinje neurons plays a critical role in the pathology in spinocerebellar ataxias.
    1. Structural Biology and Molecular Biophysics

    Dynamic action of the Sec machinery during initiation, protein translocation and termination

    Tomas Fessl et al.
    The complex process of protein translocation across membranes has been dissected into multiple key steps and the distributions of translocation rates indicate stochastic nature of the reaction.
    1. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.

Refine your results by:

Type
Research categories