57 results found
    1. Developmental Biology
    2. Neuroscience

    MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons

    Caitlin Engelhard, Sarah Sarsfield ... David D Ginty
    A protein called Megf8 regulates the activity of key signaling molecules involved in the development of the peripheral nervous system.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua, Philip M Smallwood, Jeremy Nathans
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Neuroscience

    CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

    Margherita Farina, Rhea van de Bospoort ... Ruud F Toonen
    Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane.
    1. Cell Biology
    2. Neuroscience

    The unfolded protein response is required for dendrite morphogenesis

    Xing Wei, Audrey S Howell ... Kang Shen
    The unfolded protein response regulates neuronal dendrite morphogenesis by controlling the folding of a transmembrane leucine-rich repeat (LRR) protein.
    1. Developmental Biology
    2. Neuroscience

    Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons

    Thomas M Coate, Nathalie A Spita ... Matthew W Kelley
    The development of the mammalian cochlea undergoes a period of embryonic refinement in which the outer hair cell region repels incoming type I spiral ganglion neurons, thus ensuring these neurons instead form connections with inner hair cells.
    1. Developmental Biology
    2. Neuroscience

    Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

    Xuecai Ge, Ljiljana Milenkovic ... Matthew P Scott
    Neuropilin integrates with Hedgehog signal transduction by a newly identified transducer to control cerebellar neurogenesis and medulloblastoma.
    1. Cell Biology
    2. Neuroscience

    Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

    Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
    The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.
    1. Developmental Biology
    2. Neuroscience

    Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

    Abhishek Kulkarni, Deniz Ertekin ... Thomas Hummel
    Timing in the formation of neurons influences synaptic connectivity.
    1. Ecology
    2. Microbiology and Infectious Disease

    A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis

    Emilie-Fleur Neubauer, Angela Z Poole ... Virginia M Weis
    The colonization of corals and their relatives by intracellular microalgae is facilitated by immunity proteins in the animal that contain thrombospondin-type-1 repeats, elucidating the inter-partner recognition processes required for the establishment of this ecologically important symbiosis.
    1. Developmental Biology
    2. Neuroscience

    The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

    Xiaojun Xie, Masashi Tabuchi ... Alex L Kolodkin
    The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.

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