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    1. Developmental Biology
    2. Genetics and Genomics

    Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

    Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon
    HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
    1. Developmental Biology

    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

    Ann Kathrin Heilig, Ryohei Nakamura ... Toru Kawanishi
    A medaka mutant revealed that Wnt11 promotes formation of uniquely large protrusions from non-myogenic dorsal dermomyotome cells, which guide the epaxial myotome dorsally to achieve the coverage of the neural tube.
    1. Developmental Biology
    2. Neuroscience

    Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

    Catarina Catela, Yihan Chen ... Paschalis Kratsios
    Molecular, genetic, and behavioral assays in mice establish a new role for Hox proteins in the final steps of spinal motor neuron development.
    1. Developmental Biology

    Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

    Mai Ahmed, Yutaka Kojima, Ichiro Masai
    A neuroprotective role mediated by Strip1 maintains retinal ganglion cells during development, which ensures proper positioning of inner retinal neurons and preserves the laminar architecture of the inner retina.
    1. Cell Biology
    2. Developmental Biology

    Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

    Jialing Qi, Annegret Rittershaus ... Christian SM Helker
    Apelin signaling-dependent endocardial protrusions promote cardiac trabeculation through Nrg/ErbB/Erk signaling in zebrafish.
    1. Developmental Biology
    2. Neuroscience

    Role of Nrp1 in controlling cortical inter-hemispheric circuits

    Fernando Martín-Fernández, Ana Bermejo-Santos ... Marta Nieto
    Transient expression of Nrp1 is required in postnatal stages for terminal arborization and innervation of secondary areas during the development of somatosensory callosal circuits.
    1. Cancer Biology
    2. Genetics and Genomics

    Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

    Oscar Urtatiz, Amanda Haage ... Catherine D Van Raamsdonk
    G alpha q/11 signaling can either promote or inhibit melanocyte growth through a reversible switch that is controlled by the microenvironment and that shapes the mutational diversity of melanoma subtypes.
    1. Developmental Biology
    2. Neuroscience

    CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway

    Benoît Boulan, Charlotte Ravanello ... Jean-Christophe Deloulme
    CRMP4 is a new actor in the guidance cue Semaphorin-3E pathway, crucially involved in the establishment of the fornix, a key axonal tract for memory and emotional control.
    1. Cell Biology
    2. Neuroscience

    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

    Blake A Creighton, Simone Afriyie ... Damaris N Lorenzo
    Giant ankyrin-B enables the transduction of Sema 3A repelling cues and is important for normal axonal connectivity.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla, Marcos Assis Nascimento ... Arturo Álvarez-Buylla
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.