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    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin, Maria Brbić ... Hongjie Li
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Cell Biology
    2. Neuroscience

    The unfolded protein response is required for dendrite morphogenesis

    Xing Wei, Audrey S Howell ... Kang Shen
    The unfolded protein response regulates neuronal dendrite morphogenesis by controlling the folding of a transmembrane leucine-rich repeat (LRR) protein.
    1. Cell Biology
    2. Neuroscience

    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

    Blake A Creighton, Simone Afriyie ... Damaris N Lorenzo
    Giant ankyrin-B enables the transduction of Sema 3A repelling cues and is important for normal axonal connectivity.
    1. Cell Biology
    2. Neuroscience

    Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

    Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
    The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.
    1. Developmental Biology
    2. Neuroscience

    Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

    Xuecai Ge, Ljiljana Milenkovic ... Matthew P Scott
    Neuropilin integrates with Hedgehog signal transduction by a newly identified transducer to control cerebellar neurogenesis and medulloblastoma.
    1. Neuroscience

    Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

    Tyler G Ekins, Vivek Mahadevan ... Chris J McBain
    An excess of novel non-canonical subtypes of parvalbumin+ interneurons in a mouse model of classical lissencephaly, which possess non-fast-spiking physiological properties, may contribute to network hyperexcitability common in this model.
    1. Neuroscience

    Robo functions as an attractive cue for glial migration through SYG-1/Neph

    Zhongwei Qu, Albert Zhang, Dong Yan
    An extracellular cleavage fragment of Robo released from neurons can bind to glia-expressed SYG-1 to guide glia migration.
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook, Catia Sousa ... Roger J Keynes
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Developmental Biology
    2. Immunology and Inflammation

    Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain

    Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado ... Ralf H Adams
    Reactive endothelial venules are a new vessel subtype characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophages, and the initiation of CNS immune responses.
    1. Cell Biology
    2. Developmental Biology

    Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

    Jialing Qi, Annegret Rittershaus ... Christian SM Helker
    Apelin signaling-dependent endocardial protrusions promote cardiac trabeculation through Nrg/ErbB/Erk signaling in zebrafish.