143 results found
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon, Catherine Theriault ... Arjun Krishnaswamy
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Immunology and Inflammation
    2. Neuroscience

    The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

    Xiao-Feng Zhao, Lucas D Huffman ... Roman J Giger
    Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
    1. Computational and Systems Biology
    2. Neuroscience

    Deciphering the genetic code of neuronal type connectivity through bilinear modeling

    Mu Qiao
    A novel bilinear modeling approach reveals genetic code of neuronal connectivity, offering insights for targeted genetic interventions in neural circuits.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi, Ralph Patrick ... Richard P Harvey
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Cell Biology
    2. Immunology and Inflammation

    DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress

    Fabian Hersperger, Tim Meyring ... Katrin Kierdorf
    Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Developmental Biology
    2. Neuroscience

    UNC-6/Netrin promotes both adhesion and directed growth within a single axon

    Ev L Nichols, Joo Lee, Kang Shen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

    Kevin Beier
    A modified viral strategy reveals that ventral tegmental area dopamine cells receive substantial inputs from local sources, including distributed GABAergic and serotonergic inputs from the midbrain as well as extensive inputs from other midbrain dopamine cells.
    1. Developmental Biology

    Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

    Jiangnan Luo, Chun-Yuan Ting ... Chi-Hon Lee
    Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.

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