A mutant rescue approach in STX1-null autaptic neurons provides definitive answers and opens up new questions into a controversial matter of syntaxin-1's binding to Munc18-1 through its N-peptide and its function in neurotransmission.
FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.
Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.