PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.

Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.

Changes in Shank gene dosage alter voltage-activated calcium current and calcium-activated gene expression in a manner that parallels the effects of human Shank copy number variation on psychiatric disease risk.

Two optically transparent substrates enable the exploration of the ecophysiology and spatiotemporal organization and activities of bacteria and fungi within heterogeneous soil-like environments.

Habitats of satellite-tracked blue sharks were shifted surfaceward by an oxygen minimum zone (OMZ) at depth thereby increasing their susceptibility to capture by longline fishing focused above the OMZ.

Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive structural conformation.

Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.

Metastases-associated fibroblasts show stage-dependent transcriptional plasticity and their rewiring is regulated by Myc.

The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.

The regulatory switch from protection to assimilation, which plants use to exploit natural, fluctuating light, involves movement of the enzyme ferredoxin:NADP(H) oxidoreductase between chloroplast membrane complexes.