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    1. Developmental Biology

    Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling

    Yi Wang et al.
    Cells in tendon sheaths, considered to be extrinsic tissues of tendon, possess stem or progenitor cell properties that are involved in tendon repair by activating the Hh-TGFb/Smad3 axis.
    1. Neuroscience

    miR-9 regulates basal ganglia-dependent developmental vocal learning and adult vocal performance in songbirds

    Zhimin Shi et al.
    Gene manipulation combined with behavior analysis reveals a role of miR-9 in modulating basal-ganglia-dependent developmental vocal learning and adult vocal performance via regulating the FOXP1/FOXP2 gene network and dopamine signaling in songbirds.
    1. Developmental Biology

    Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice

    Yu Shi, Fanxin Long
    Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
    1. Genetics and Genomics

    Insulin-like peptides and the mTOR-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death

    Cheng Shi et al.
    Hermaphroditic Caenorhabditis elegans slow the onset of mating-induced death through self-sperm-regulated insulin-like gene expression, which regulates the activity of the IIS/FOXO pathway, mTOR signaling, and the TFEB/HLH-30 transcription factor.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

    Silvia Peluso et al.
    FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
    1. Neuroscience

    Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

    Zhigang Shi et al.
    Leptin acts in the paraventricular nucleus to slowly increase sympathetic nerve activity to skeletal muscle and brown adipose tissue via induction of its own receptor in TRH glutamatergic neurons.
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of phospholipid activation of the human TPC2 channel

    Ji She et al.
    Cryo-EM structures of human TPC2 channel in the ligand-bound and apo states reveal the structural mechanism of PI(3,5)P2 lipid regulated gating of TPC2.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

    Neel H Shah et al.
    A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
    1. Developmental Biology
    2. Evolutionary Biology

    Mating and male pheromone kill Caenorhabditis males through distinct mechanisms

    Cheng Shi et al.
    Male C. elegans die through two distinct mechanisms – mating-induced germline activation, and potent male pheromone toxicity – but the latter is unique to males of androdioecious species (made up of hermaphrodites and males).
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao et al.
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.