160 results found
    1. Medicine

    Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

    Jonathan R Volpatti et al.
    A multi-species chemical screening platform reveals a conserved role for p38 inhibition in modulating ryanodine receptor-related phenotypes and is adaptable to a range of neuromuscular disorders.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Neuroscience

    The functional organization of excitation and inhibition in the dendrites of mouse direction-selective ganglion cells

    Varsha Jain et al.
    Accurate direction-selective information is present within small sections of the dendrites, raising the possibility that single dendrites utilize parallel processing schemes to process motion information.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Physics of Living Systems
    2. Neuroscience

    Physical limits to magnetogenetics

    Markus Meister
    Recent reports on the ability of biological molecules to sense magnetic fields are found to be inconsistent with basic physical principles.
    1. Computational and Systems Biology
    2. Neuroscience

    Prediction of primary somatosensory neuron activity during active tactile exploration

    Dario Campagner et al.
    Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Developmental Biology
    2. Neuroscience

    The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

    Joseph G Duman et al.
    The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
    1. Neuroscience

    Representational untangling by the firing rate nonlinearity in V1 simple cells

    Merse E Gáspár et al.
    Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.

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