12 results found
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Cell Biology
    2. Developmental Biology

    Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

    Austin T Baldwin, Juliana H Kim ... John B Wallingford
    Tissue-level cell tracking and analysis of actomyosin and N-cadherin adhesion dynamics, coupled with disruption of the regulatory gene Shroom3, reveals region-specific cell behaviors along the anteroposterior axis during neural tube closure.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz, Nicola Victoria Müller ... Reinhold Kreutz
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Cell Biology
    2. Developmental Biology

    Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

    Torey R Arnold, Joseph H Shawky ... Ann L Miller
    In epithelial cells, anillin organizes the medial-apical actomyosin cortex into a contractile load-bearing structure and increases tissue-level stiffness.
    1. Developmental Biology
    2. Genetics and Genomics

    Systematic imaging reveals features and changing localization of mRNAs in Drosophila development

    Helena Jambor, Vineeth Surendranath ... Pavel Tomancak
    Genome wide analysis reveals that many transcripts are localized in cells of the ovary and that the localization status of mRNAs changes over time and in different cell types.
    1. Cell Biology
    2. Developmental Biology

    Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

    Eric R Brooks, Mohammed Tarek Islam ... Jennifer A Zallen
    Closure of the cranial neural tube, which is essential for mammalian development, is driven by spatially and temporally patterned cell remodeling events that require positionally regulated Sonic hedgehog signaling.
    1. Biochemistry and Chemical Biology

    Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

    Theresa Hwang, Sara S Parker ... Amy E Keating
    Short linear motifs throughout the intrinsically disordered proteome use sequence context in diverse ways to target actin remodeler ENAH.
    1. Developmental Biology

    Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

    Sobhika Agarwala, Sandra Duquesne ... Virginie Lecaudey
    The cell junction-associated protein Amotl2a controls tissue size in the zebrafish lateral line primordium by limiting the activity of the Hippo effector Yap1 and the Wnt effector Lef1.
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Not revised
    Reviewed Preprint v1

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