67 results found
    1. Genetics and Genomics

    Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

    Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
    A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.
    1. Structural Biology and Molecular Biophysics

    Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake

    Inokentijs Josts, Katharina Veith, Henning Tidow
    The crystal structure of a ternary complex of a TonB-dependent transporter containing a signalling domain, bound to siderophore as well as TonB, provides mechanistic insights into siderophore uptake and signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii

    Lucile Moynié, Ilaria Serra ... James H Naismith
    The pathogen Acinetobacter baumannii recognises preacinetobactin not acinetobactin, yet appears likely to translocate both compounds through a mixed complex.
    1. Microbiology and Infectious Disease

    Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus

    Lea Antje Adolf, Angelika Müller-Jochim ... Simon Heilbronner
    Staphylococcal heme acquisition needs a highly structured cell envelope, the membrane transporter accumulates in membrane domains most likely to allow concerted passage of heme from the cell wall-funnel to the membrane.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

    Vera Vollenweider, Karoline Rehm ... Rolf Kümmerli
    Iron-chelating pyoverdines from environmental Pseudomonas spp. show promising antibacterial activity against key human pathogens through the induction of iron starvation, while associated toxicity for host systems remains low.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham, Benjamin E Wolfe, Rachel J Dutton
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

    Markus Gressler, Florian Meyer ... Matthias Brock
    Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.
    1. Ecology
    2. Microbiology and Infectious Disease

    Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci
    12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

    Annah S Rolig, Emily Goers Sweeney ... Karen Guillemin
    Discovery of a secreted protein from resident gut bacteria that reduced intestinal innate immune responses which would otherwise simultaneously compromise both bacterial and host survival.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

    Alba Pacheco-Moreno, Francesca L Stefanato ... Andrew W Truman
    Genomics and genetics were used to identify specialized metabolites employed by Pseudomonas bacteria to suppress the growth of potato pathogens, which revealed a key role for cyclic lipopeptides.

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