71 results found
    1. Immunology and Inflammation

    Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

    Guo-Yun Chen et al.
    Sialoside-based pattern recognition by Siglecs directly regulates toll-like receptor signaling and a sialidase inhibitor protects against endotoxemia.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Siglec receptors impact mammalian lifespan by modulating oxidative stress

    Flavio Schwarz et al.
    By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
    1. Cancer Biology

    Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

    Rohit Singh, Beom K Choi
    When pioneer metastatic cells enter a sentinel lymph node through afferent lymphatics subcapsular sinus, macrophages provide them soil to proliferate and colonize lymph node.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont et al.
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.
    1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Immunology and Inflammation

    Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis

    Nicholas A Spidale et al.
    Neonatal-origin dermal Tγδ17 cells are required to maintain normal keratinocytes and prevent spontaneous atopic dermatitis.
    1. Immunology and Inflammation

    B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

    Eric E Irons et al.
    B cells regulate production of neutrophils by a novel mechanism by releasing ST6Gal-1, an active sialyltransferase, that suppresses granulopoiesis.

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