2,761 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Real-time observation of signal recognition particle binding to actively translating ribosomes

    Thomas R Noriega et al.
    The signal recognition particle only stably engages translating ribosome nascent-chain complexes exposing a functional signal sequence.
    1. Biochemistry and Chemical Biology

    Circularization restores signal recognition particle RNA functionality in Thermoproteus

    André Plagens et al.
    Archaea can contain permuted versions of the universal signal recognition particle RNA, which require a moonlighting activity of the tRNA splicing machinery to generate functional circular RNAs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

    Yu-Hsien Hwang Fu et al.
    Single molecule microscopy combined with biochemical analyses show that a two-step lipid-binding mechanism of the SRP receptor balances the trade-off between speed and specificity during co-translational protein targeting.
    1. Neuroscience

    Dynamic representation of partially occluded objects in primate prefrontal and visual cortex

    Amber M Fyall et al.
    Complementary neural codes in frontal and visual cortex support a role for feedback signals in the representation and recognition of partially occluded objects.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A functional link between the co-translational protein translocation pathway and the UPR

    Rachel Plumb et al.
    Ire1α co-opts the Sec61 translocon channel to efficiently cleave its mRNA substrates during endoplasmic reticulum stress conditions.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

    Nir Fluman et al.
    Translation pauses occur in strategic positions to facilitate the production of properly folded membrane proteins in bacteria.
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt et al.
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The guide sRNA sequence determines the activity level of box C/D RNPs

    Andrea Graziadei et al.
    Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.

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