384 results found
    1. Medicine

    Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

    Salwa Naushin, Viren Sardana ... Shantanu Sengupta
    Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.
    1. Biochemistry and Chemical Biology

    Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

    Ornella Bimai, Ipsita Banerjee ... Derek T Logan
    The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

    Max Renner, Mattia Bertinelli ... Jonathan M Grimes
    A structural comparison of different states of the protein responsible for encapsidation of the viral RNA genome provides mechanistic insights into this process.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt, Matthew R Hayward ... Peer Bork
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.
    1. Neuroscience

    Human and macaque pairs employ different coordination strategies in a transparent decision game

    Sebastian Moeller, Anton M Unakafov ... Igor Kagan
    Using novel approach to study real-time social interactions shows that mutual action visibility facilitates static and dynamic coordination in both species, but whereas humans employ dynamic turn-taking to equalize rewards, macaques, after training with a human, compete between themselves.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

    Christopher G Jacob, Nguyen Thuy-Nhien ... Olivo Miotto
    Large-scale genetic surveillance of malaria implemented by National Malaria Control Programmes informs public health decision makers about the spread of strains resistant to antimalarials.
    1. Ecology
    2. Computational and Systems Biology

    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    Iva Veseli, Yiqun T Chen ... A Murat Eren
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Physics of Living Systems

    A first order phase transition mechanism underlies protein aggregation in mammalian cells

    Arjun Narayanan, Anatoli Meriin ... Ibrahim I Cisse
    Quantitative single molecule and super resolution imaging in mammalian cells reveal a population of precursor aggregates describable by first order phase transition theory.
    1. Neuroscience

    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

    David Oestreicher, Shashank Chepurwar ... Tina Pangrsic
    Analysis of Cabp1/2 double knockout phyenotype and rescue by viral delivery of Cabp2 identifies the interplay between two CaBPs to promote sustained synaptic transmission at the inner hair cell synapses.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

    Claudia C Carcamo, Matthew F Poyton ... Taekjip Ha
    In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.

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