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    1. Structural Biology and Molecular Biophysics

    A lipid bound actin meshwork organizes liquid phase separation in model membranes

    Alf Honigmann, Sina Sadeghi ... Richard Vink
    A combination of imaging experiments and computer simulations on a model lipid membrane integrate the 'picket fence' and 'raft' models, and suggest that the interplay between actin binding, lipid phase separation and curvature compartmentalize the membrane.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli, Houman Safaai ... Davide Zoccolan
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Cell Biology

    ATR expands embryonic stem cell fate potential in response to replication stress

    Sina Atashpaz, Sara Samadi Shams ... Vincenzo Costanzo
    ATR protects stem cell genomes by activating a transcriptional response mediated by totipotency genes, conferring trophoblast differentiation potential, the derepression of which in somatic cells might favour cancer features emergence.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Computational and Systems Biology

    Dynamic control of gene regulatory logic by seemingly redundant transcription factors

    Zohreh AkhavanAghdam, Joydeb Sinha ... Nan Hao
    Seemingly redundant homologous transcription factors play distinct and cooperative roles in time-dependent combinatorial gene regulation and enable dynamic control of heterogeneity in the gene responses to environmental stresses.
    1. Physics of Living Systems

    Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis

    Rajsekhar Das, Sumit Sinha ... D Thirumalai
    Theoretical explanation and a novel mechanism are given for the observation that viscosity of embryonic non-confluent tissue shows glass-like behavior till a critical cell density and saturates at higher densities.
    1. Biochemistry and Chemical Biology

    Diverse nucleosome Site-Selectivity among histone deacetylase complexes

    Zhipeng A Wang, Christopher J Millard ... Philip A Cole
    By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
    1. Ecology
    2. Genetics and Genomics

    Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks

    Beryl M Jones, Vikyath D Rao ... Gene E Robinson
    Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
    1. Chromosomes and Gene Expression

    Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers

    Erick E Nakagaki-Silva, Clare Gooding ... Christopher WJ Smith
    By focusing on RNA-binding proteins whose genes have super enhancers in smooth muscle cells, the protein RBPMS was identified as an alternative splicing master regulator.