12 results found
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

    Charlotte Lässig et al.
    RIG-I Singleton-Merten syndrome mutations either mimic or freeze the protein in an ATP-bound state and lead to autoimmune signalling through a gain-of-function recognition of self-RNA.
    1. Cell Biology
    2. Immunology and Inflammation

    ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

    Charlotte Lässig et al.
    Mutations within the ATPase domain of RIG-I in patients with Singleton-Merten Syndrome prevent ATP-hydrolysis dependent dissociation of RIG-I from double-stranded RNA and lead to unintentional constitutive signaling through increased binding of endogenous RNA.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

    Ignacio Mena et al.
    Genome sequence data from 58 Mexican swine influenza A viruses resolves the spatial origin of the virus that originated the influenza pandemic of 2009.
    1. Medicine
    2. Immunology and Inflammation

    Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

    Allison M Owen et al.
    Sepsis-induced long-term muscle weakness was reproduced using a refined murine model, which was accompanied by mitochondrial dysfunction in the absence of sustained atrophy, suggesting the promise of mitochondria-targeted post-sepsis therapies.
    1. Neuroscience

    Microtubule-dependent ribosome localization in C. elegans neurons

    Kentaro Noma et al.
    The utility of split GFP for tissue-specific visualization of ribosomes in live Caenorhabditis elegans demonstrates the link between ribosomes and microtubules.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The effect of hybridization on transposable element accumulation in an undomesticated fungal species

    Mathieu Hénault et al.
    Transposable elements are not reactivated in natural hybrids of the yeast Saccharomyces paradoxus, but their accumulation is genotype-specific and is not predicted by the evolutionary divergence between a hybrid's parents.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang et al.
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Immunology and Inflammation

    Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

    Sofya A Kasatskaya et al.
    Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.

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