534 results found
  1. Episode 43: November 2017

    In this episode, we hear about tool use in monkeys, sleep regulation, marsupial placentas, health campaigns and why science papers are so hard to read.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Computational and Systems Biology
    2. Developmental Biology

    A balance of positive and negative regulators determines the pace of the segmentation clock

    Guy Wiedermann et al.
    Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez et al.
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Neuroscience

    A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

    Xia-Jing Tong et al.
    Mobile and immobile GABAA receptors in the C. elegans neuromuscular synapse are stabilized by two distinct protein scaffolds.
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen et al.
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.
    1. Developmental Biology
    2. Genetics and Genomics

    MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

    Meltem Weger et al.
    The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.

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