14,710 results found
    1. Microbiology and Infectious Disease

    Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota

    Daniel Hoces, Giorgia Greter ... Emma Slack
    Neutral tagging and detailed analysis of bacterial growth kinetics can quantify the mechanisms of colonization resistance in differently colonized animals.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Microbiology and Infectious Disease

    Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State

    Louise H Moncla, Allison Black ... Trevor Bedford
    Social networks can be the primary risk factor for mumps infection and transmission, regardless of age and vaccination status.
    1. Structural Biology and Molecular Biophysics

    Structural basis for the phase separation of the chromosome passenger complex

    Nikaela W Bryan, Aamir Ali ... Ben E Black
    The utilization of hydrogen/deuterium exchange mass spectrometry reveals dynamic insights and interactions driving liquid-liquid demixing of the chromosome passenger complex.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

    Anthony J Linares, Chia-Ho Lin ... Douglas L Black
    The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

    Somsakul Pop Wongpalee, Ajay Vashisht ... Douglas L Black
    A protein regulator of alternative pre-mRNA splicing arrests spliceosome assembly at a previously unrecognized step that defines new intermediate stages in the formation of exon complexes.
    1. Cell Biology
    2. Neuroscience

    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

    Holly H Black, Jessica L Hanson ... Alexandra M Whiteley
    Exploring how UBQLN2 mutations cause ALS leads to the discovery of a pathway by which an ancient retroelement changes gene expression in human cells.
    1. Neuroscience

    A platform for brain-wide imaging and reconstruction of individual neurons

    Michael N Economo, Nathan G Clack ... Jayaram Chandrashekar
    High-resolution fluorescence imaging of the complete mouse brain enables many neurons to be efficiently visualized in their entirety, revealing all targets of neurons that project widely across the brain.
    1. Cell Biology

    The quantitative architecture of centromeric chromatin

    Dani L Bodor, João F Mata ... Lars ET Jansen
    The number of CENP-A molecules at human centromeres helps to explain how this structure is built and epigenetically inherited.
    1. Neuroscience

    Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

    Tian Yuan, Yifan Wang ... Zhuo Huang
    Unveiling NaV1.6's role in sensitizing Slack to quinidine disruption redefines KCNT1-related epilepsy treatment strategies.

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