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    1. Cell Biology

    ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

    Shimin Wang, Hongxian Wang ... Dong Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal, Wei-Hsiang Huang ... Paul A Gray
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Stem Cells and Regenerative Medicine

    Rejuvenating aged osteoprogenitors for bone repair

    Joshua Reeves, Pierre Tournier ... Shukry J Habib
    Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.
    1. Neuroscience

    Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

    Alyssa D Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    Glutamatergic–cholinergic neurons in the postinspiratory complex are critical for swallow motor patterning and the coordination of swallow and breathing, which is disrupted by chronic intermittent hypoxia, a condition seen in many disorders associated with dysphagia and aspiration pneumonia.
    1. Evolutionary Biology
    2. Medicine

    The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
    An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.
    1. Immunology and Inflammation

    Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    Chongbin Hu, Nan Zhang ... Jian-zhong Shao
    scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Developmental Biology
    2. Neuroscience

    Automated deep-phenotyping of the vertebrate brain

    Amin Allalou, Yuelong Wu ... Mehmet Fatih Yanik
    Automated whole-brain analysis of gene expression at cellular resolution detects previously overlooked phenotypes in mutants and reveals parallels between the forebrains of zebrafish and mammals.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger, Wengang Wang ... Bernardo L Sabatini
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.