The reduction of bicarbonate secretion into the airways reproduces cystic fibrosis-like features, independently of chloride secretion.

Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.

Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.

In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.

SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.

The ISR kinase GCN2 is critical for maintaining tumor amino acid levels to facilitate growth, suggesting a novel therapeutic strategy for the treatment of prostate cancer by inducing starvation for essential amino acids.

Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO₃ precipitation under changing environmental conditions.

Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.

The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.

Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.