294 results found
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Developmental Biology
    2. Neuroscience

    Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

    Karina Chaudhari et al.
    Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Developmental Biology
    2. Neuroscience

    Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2

    Verity Johnson et al.
    ROBO isoforms with minute sequence variations have significant and distinct functions in axon guidance.
    1. Neuroscience

    Robo functions as an attractive cue for glial migration through SYG-1/Neph

    Zhongwei Qu et al.
    An extracellular cleavage fragment of Robo released from neurons can bind to glia-expressed SYG-1 to guide glia migration.
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing et al.
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.
    1. Neuroscience

    Stretching the skin immediately enhances perceived stiffness and gradually enhances the predictive control of grip force

    Mor Farajian et al.
    Elucidating the contribution of augmented artificial skin-stretch stimulation to the fingertips to the immediate illusion of a higher stiffness and to an increased predictive grip force control.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Tunable protein synthesis by transcript isoforms in human cells

    Stephen N Floor, Jennifer A Doudna
    Measurements of transcript isoform specific translation across the human genome reveal that isoforms from the same gene can differ in protein production by two orders of magnitude.
    1. Cell Biology
    2. Developmental Biology

    Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland

    Yangguang Hao, Li Hua Jin
    Jumu is required for the proper differentiation of prohemocytes and the proliferation and location of PSC cells.

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