425 results found
    1. Neuroscience

    High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

    Jian Qiu et al.
    Kisspeptin neurons in the hypothalamus release peptide and amino acid neurotransmitters that work together to coordinate the activity of gonadotropin-releasing hormone neurons and subsequent release of reproductive hormones.
    1. Neuroscience

    Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity

    Scott L Jones et al.
    The activation of small-conductance calcium-activated potassium channels in spines by action potentials regulates the induction of spike-timing dependent synaptic plasticity during low-frequency single action potential–EPSP pairing.
    1. Neuroscience

    Reproduction: A kiss to set the rhythm

    Sonal Shruti, Vincent Prevot
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    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Computational and Systems Biology
    2. Neuroscience

    Fast and flexible sequence induction in spiking neural networks via rapid excitability changes

    Rich Pang, Adrienne L Fairhall
    Biologically plausible changes in the excitabilities of single neurons may suffice to selectively modulate sequential network dynamics, without modifying of recurrent connectivity.
    1. Neuroscience

    Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

    Christina Chatzi et al.
    Single episodes of voluntary exercise induced a functional increase in hippocampal synapses mediated by activity-dependent expression of the BAR protein Mtss1L, acting as a novel early effector of synapse formation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Ion counting demonstrates a high electrostatic field generated by the nucleosome

    Magdalena Gebala et al.
    First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.
    1. Neuroscience

    A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

    David Goyer et al.
    VIP neurons are a novel class of inferior colliculus stellate neurons that project to long-range auditory and non-auditory targets and integrate inputs from the auditory brainstem and contralateral IC.

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