5 results found
    1. Physics of Living Systems

    Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

    Thomas C Day, Stephanie S Höhn ... Peter J Yunker
    The distributions of cellular neighborhood volumes in two very different multicellular species - snowflake yeast and Volvox carteri - are found to obey a common functional form arising from maximum entropy consideration, despite great differences in their cell division processes.
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Evolutionary Biology

    Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

    Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
    A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

    Koshlan Mayer-Blackwell, Stefan Schattgen ... Andrew Fiore-Gartland
    Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.
    1. Neuroscience

    Against cortical reorganisation

    Tamar R Makin, John W Krakauer
    A critical re-evaluation of some of the quintessential examples given as evidence for cortical reorganisation argues that, contrary to the prevalent view, any opportunities for functional change in cortical organisation are incremental and constrained by the underlying structural ‘blueprint'.

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