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    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

    Dana Gancz et al.
    Cardiac lymphatic vessels of heterogeneous origins and molecular signatures support cardiac growth and regeneration.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic et al.
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Association mapping from sequencing reads using k-mers

    Atif Rahman et al.
    Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.
    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli et al.
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Neuroscience

    A corticostriatal deficit promotes temporal distortion of automatic action in ageing

    Miriam Matamales et al.
    Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.
    1. Structural Biology and Molecular Biophysics

    Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery

    Bertram Daum et al.
    Using both electron cryo-tomography and helical reconstruction, the first structure of the entire archaellum machinery with an assembled filament has been determined, providing the structural basis for our understanding of archaeal motility.
    1. Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann et al.
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    1. Cell Biology

    A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

    Matthias Christoph Munder et al.
    The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

    Jason Tien et al.
    The identification of four acidic amino acids as potential calcium-binding residues in the TMEM16A calcium-activated chloride channel furthers the molecular understanding of this ion channel family.