65 results found
    1. Neuroscience

    Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees

    Santosh Chandrasekaran, Ameya C Nanivadekar ... Lee E Fisher
    Cervical spinal cord stimulation evokes sensory percepts in the missing hand and arm of people with upper-limb amputation, regardless of amputation level or time post-amputation.
    1. Neuroscience

    Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation

    Michelle Armenta Salas, Luke Bashford ... Richard A Andersen
    Electrical microstimulation of human somatosensory cortex elicited purely naturalistic proprioceptive and cutaneous sensations, with proprioceptive sensations more prominent at higher current amplitudes suggesting a relationship between amplitude and sensation type.
    1. Neuroscience

    Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Isaac M Chiu, Lee B Barrett ... Clifford J Woolf
    Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.
    1. Neuroscience

    Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

    Minh Q Nguyen, Lars J von Buchholtz ... Steve Davidson
    Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
    1. Cell Biology

    Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

    Pratibha Narayanan, Meike Hütte ... Manuela Schmidt
    Local Mtmr2 activity and PI(3,5)P2 abundance dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons.
    1. Neuroscience

    Keratinocytes contribute to normal cold and heat sensation

    Katelyn E Sadler, Francie Moehring, Cheryl L Stucky
    Purinergic keratinocyte-to-sensory neuron signaling is a ubiquitous amplification mechanism that is required for normal mechanical, cold, and heat sensation in vivo.
    1. Neuroscience

    NaV1.1 is essential for proprioceptive signaling and motor behaviors

    Cyrrus M Espino, Cheyanne M Lewis ... Theanne N Griffith
    The voltage-gated sodium channel Nav1.1 is identified as an essential component of the proprioceptive transmission machinery that is required in vivo for normal motor behavior.
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu, Anastasia Chrysidou ... Esther Kuehn
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Neuroscience

    Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs

    Ara Schorscher-Petcu, Flóra Takács, Liam E Browne
    A system to generate ‘remote touch’ in freely behaving mice can be utilized to map behavior caused by precise somatosensory inputs.
    1. Neuroscience

    Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

    Minh Q Nguyen, Claire E Le Pichon, Nicholas Ryba
    Peripheral injury induces a programmed but reversible transformation of gene expression in somatosensory neurons providing a mechanism to regulate sensory input during wound healing.

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