SPRTN is a protease essential for the repair of cytotoxic DNA-protein cross links and this function is defective in patients afflicted with Ruijs-Aalfs syndrome -a segmental progeroid syndrome.

During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.

Aneuploidy can cause chromosome mis-segregation and specific cellular phenotypes driven by expression of genes on the extra chromosome.

C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.

The dynamics and functions of epidermal microtubules are revealed through the use of transgenic tools to image and perturb microtubule arrays.

BLITZ system enables proximity-dependent biotin labelling in live zebrafish embryos with cell and tissue specificity, providing a versatile and valuable tool for proteomic discovery using the zebrafish model.

Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.

New insights into the assembly and membrane interactions of the caveolar coat complex reveal the reversible association/dissociation of distinct subcomplexes onto the membrane, which differs from the assembly/disassembly of clathrin-coated pits.

During Staphylococcus aureus infections, bacterial cells bifurcate into distinct, specialized cell types that localize physically in different colonization tissues to simultaneously generate different infection types.

Neural stem cells in the dentate gyrus have unique cytoplasmic processes that promote privileged access to circulating factors by a unique contact point with an endothelial cell.