2,222 results found
    1. Cell Biology

    Evidence that a positive feedback loop drives centrosome maturation in fly embryos

    Ines Alvarez-Rodrigo et al.
    Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
    1. Cell Biology

    Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

    Kenji Sugioka et al.
    A genetic screen and live cell imaging show that a newly identified coiled-coil protein called SAS-7 is the earliest acting factor in centriole assembly yet identified in the roundworm Caenorhabditis elegans.
    1. Cell Biology
    2. Developmental Biology

    A molecular mechanism of mitotic centrosome assembly in Drosophila

    Paul T Conduit et al.
    The proteins DSpd-2 and Centrosomin assemble into dynamic scaffolds that build from the inside out around the mother centriole and support centrosome maturation.
    1. Cancer Biology

    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

    Tessa M Popay et al.
    Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

    Elizabeth A Hubin et al.
    The essential mycobacterial transcription factor RbpA interacts with promoter DNA and cooperates with another essential transcription factor, CarD, to stimulate the formation of an intermediate leading to the open promoter complex.
    1. Structural Biology and Molecular Biophysics

    Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

    My-Tra Le et al.
    Folding and unfolding pathways are described for a ribosome-binding 3' cap-independent translation enhancer at the center of a conformational rearrangement that is implicated in the transition from translation to replication of an RNA virus.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

    Viktoria Désirée Paul et al.
    Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap et al.
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

    Evanthia Zacharioudaki et al.
    Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

    Jinsheng Zhu et al.
    Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.

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