669 results found
    1. Cell Biology
    2. Physics of Living Systems

    Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus

    Benjamin Seelbinder, Susan Wagner ... Moritz Kreysing
    Localized temperature gradients used as a novel method of active micro-theology that is non-invasive and probe-free, to investigate material responses of cell departments such as the different compartments of a nucleus displaying distinct material properties.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil, Bence Rácz ... Scott H Soderling
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne, Jean-Patrick Vrel, Pierre Sens
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Genetics and Genomics

    Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

    Courtney J Smith, Nasa Sinnott-Armstrong ... Jonathan K Pritchard
    Genetic variants acting between biologically related metabolite pairs often reflect biology local to the traits and have effect directions contrasting those of upstream or downstream variants, which can result in striking, biologically interpretable heterogeneity in genetic correlation across the genome.
    1. Neuroscience

    Automated long-term recording and analysis of neural activity in behaving animals

    Ashesh K Dhawale, Rajesh Poddar ... Bence P Ölveczky
    A new automated system for recording and analyzing neural activity in behaving animals over months-long time-scales offers new perspectives on how neural circuits underlie processes such as learning, development, and recovery from brain injury.
    1. Biochemistry and Chemical Biology

    SETD3 protein is the actin-specific histidine N-methyltransferase

    Sebastian Kwiatkowski, Agnieszka K Seliga ... Jakub Drozak
    Histone-lysine N-methyltransferase SETD3 (NP_115609.2) was identified as the actin-specific histidine N-methyltransferase, an enzyme catalyzing the extremely well-conserved methylation of H73 in β-actin.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao, Alvina G Lai ... Aziz Aboobaker
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Developmental Biology

    Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool

    Theadora Tolkin, Ariz Mohammad ... David Greenstein
    Somatic gonad architecture is regulated by innexin function, but sheath cell position does not determine germ cell exit from the stem cell pool.
    1. Developmental Biology

    An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes

    Nathan D Lawson, Rui Li ... Lihua Zhu
    Computational efforts yield a zebrafish transcriptome annotation that provides more sensitive and comprehensive gene detection over existing annotations when used for bulk or single-cell RNA-seq.
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele, Rob Jelier, Pierre Gönczy
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.

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