124 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

    Nathalia Luisa Sousa de Oliveira Malacco et al.
    Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

    Aleksandra Zielińska et al.
    Correct cell wall synthesis in bacteria depends on flotillin-mediated membrane fluidity.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Immunology and Inflammation

    Resident macrophages acquire innate immune memory in staphylococcal skin infection

    Reinhild Feuerstein et al.
    Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew et al.
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

    Allison L Hicks et al.
    Sampling informed by pathogen genomic data may facilitate more efficient detection of novel antibiotic resistance than random sampling.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

    Stacie A Clark et al.
    Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
    1. Immunology and Inflammation

    Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

    Eui Ho Kim et al.
    Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim et al.
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

    Giang T Nguyen et al.
    SKAP2 is critical for hematopoietic cell protection against Klebsiella infection in mouse lungs, for full phosphorylation of Src Family Kinases, Syk, and Pyk2, and for Klebsiella-induced reactive oxygen species production.

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