12,474 results found
    1. Physics of Living Systems

    Active torque generation by the actomyosin cell cortex drives left–right symmetry breaking

    Sundar Ram Naganathan, Sebastian Fürthauer ... Stephan W Grill
    The actomyosin cytoskeleton generates active chiral torques that lead to left-right asymmetry in C. elegans embryos.
    1. Neuroscience

    Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

    Jordan G McCall, Edward R Siuda ... Michael R Bruchas
    Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.
    1. Cell Biology
    2. Physics of Living Systems

    Morphogenetic degeneracies in the actomyosin cortex

    Sundar Ram Naganathan, Sebastian Fürthauer ... Stephan W Grill
    Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.
    1. Epidemiology and Global Health

    Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trial

    Nikkil Sudharsanan, Caterina Favaretti ... Alain Vandormael
    Small changes to the way COVID-19 vaccine side-effect rates are framed and communicated have meaningful impacts on individuals' vaccination intentions.
    1. Genetics and Genomics

    Loss of centromere function drives karyotype evolution in closely related Malassezia species

    Sundar Ram Sankaranarayanan, Giuseppe Ianiri ... Kaustuv Sanyal
    The centromeres in Malassezia species, by breakage or inactivation, facilitate genome rearrangements that can result in varying karyotypes and contribute to the evolution of these species.
    1. Microbiology and Infectious Disease

    Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

    Shida Shangguan, Philip K Ehrenberg ... Rasmi Thomas
    Using single-cell CITE-seq to implicate monocytes as the cellular origin of a protective HIV vaccine gene signature.
    1. Neuroscience

    The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

    Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda
    Anatomical study reveals a new perspective on the definition of an electrical synapse where, in addition to the communicating role of gap junctions, additional cellular structures might be involved in the support and regulation of these intercellular channels.
    1. Immunology and Inflammation

    Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis

    Nicholas A Spidale, Nidhi Malhotra ... Joonsoo Kang
    Neonatal-origin dermal Tγδ17 cells are required to maintain normal keratinocytes and prevent spontaneous atopic dermatitis.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov, Hiroyuki Watanabe ... Georgy Bakalkin
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The guide sRNA sequence determines the activity level of box C/D RNPs

    Andrea Graziadei, Frank Gabel ... Teresa Carlomagno
    Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.

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