High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.

Decline in cervical cancer screening and challenges faced by healthcare professionals and patients when the pandemic was declared emphasize the importance of implementing human papillomavirus (HPV) primary screening, HPV self-sampling, and telemedicine to continue cervical cancer screening and care.

Adult spinal fracture substantially impairs subsistence productivity, particularly for men.

Socio-economic hierarchies may be bad for health, even among people living in a relatively traditional, small-scale society in the Bolivian Amazon.

A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.

A supervised learning approach on a high-content genome-wide siRNA screen has identified 591 likely candidates for ciliopathies and facilitated in the discovery of KIAA0586 mutations in individuals with Joubert syndrome.

The EB binding region defines the length of the protective cap that stabilizes growing microtubules.

Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.

A CRISPR-based genomic screen identifies the ER cargo receptor SURF4 as a key determinant in the secretion of PCSK9, a protein that regulates human cholesterol levels and cardiovascular disease risk.

Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.