A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.

Replication stress-indepedent synthetic lethality can be triggered in BRCA2-deficient cells by exploiting M phase defects.

A synthetic long-read single-cell sequencing reveals critical mutation isoform expression patterns in human liver cancer cells.

Philosophy may help to explore the potential impacts of synthetic cells.

PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.

The creation of synthetic cells and organelles will open doors to new collaborative and funding opportunities.

The independent effects of transcription factor binding sites are large regardless of sequence context, but the interactions between sites are context dependent.

Localized feedback on Fa4-Ds1 boundary complexes underlies polarized distribution of Fat4 and Ds1 and gives rise to planar cell polarity.

A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.

A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.