3,782 results found
  1. Philosophy of Biology: From primal scenes to synthetic cells

    Hub Zwart
    Philosophy may help to explore the potential impacts of synthetic cells.
    1. Cell Biology
    2. Neuroscience

    Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain

    Or David Shahar, Erin Margaret Schuman
    The development of a transgenic zebrafish allows for cell-type-specific labeling of neuronal protein synthesis, enabling brain-wide visualization and quantification of protein synthesis and demonstrating region-specific increases following elevated brain activity.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Cell Biology
    2. Computational and Systems Biology

    A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

    Olga Loza et al.
    Localized feedback on Fa4-Ds1 boundary complexes underlies polarized distribution of Fat4 and Ds1 and gives rise to planar cell polarity.
    1. Microbiology and Infectious Disease

    Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

    Jennifer A Taylor et al.
    The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
    1. Stem Cells and Regenerative Medicine

    Organoids: Synthetic scaffolds help airway cells reach maturity

    Marko Z Nikolić, Emma L Rawlins
    Insight
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    1. Cell Biology

    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

    Alexandra M Whiteley et al.
    Stimulation of cells with a mitochondria-depolarizing mitogen reveals a requirement for UBQLN1 expression in maintaining protein synthesis levels during cell cycle entry.
    1. Cell Biology

    Mammalian cell growth dynamics in mitosis

    Teemu P Miettinen et al.
    High-resolution single-cell mass accumulation and protein synthesis rate measurements are used to quantify the extent, dynamics and consequences of animal cell growth in mitosis and cytokinesis.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

    Gizem Özbaykal et al.
    For initiation of cell-wall insertion, the cross-linking enzyme PBP2 stably binds to a component of the cell envelope that is different from MreB filaments.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex

    Jordan D Carelli et al.
    An ancient complex comprising the eukaryotic elongation factor-1A and aminoacylated tRNA is shown to be the target of a cyclic heptapeptide and two unrelated natural products with potent anticancer activity.

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