Erik Bakkeren, Joana Anuschka Herter ... Wolf-Dietrich Hardt
Bacterial gut pathogens that invade into host tissues during infection can boost the spread and accumulation of plasmids over time by forming reservoirs containing these plasmids within host tissues.
Vivian Vasconcelos Costa, Michelle A Sugimoto ... Mauro Martins Teixeira
An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.
Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
Temitayo O Idowu, Valerie Etzrodt ... Sascha David
Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.