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    1. Cell Biology

    Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1

    Qi-Shan Wang, Kai-Jian Fan ... Ting-Yu Wang
    MiR 204/211 antagonize synovial inflammation and hyperproliferation by regulation of its downstream target gene Ssrp1, and decelerated RA progression.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

    Erik Bakkeren, Joana Anuschka Herter ... Wolf-Dietrich Hardt
    Bacterial gut pathogens that invade into host tissues during infection can boost the spread and accumulation of plasmids over time by forming reservoirs containing these plasmids within host tissues.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

    Vivian Vasconcelos Costa, Michelle A Sugimoto ... Mauro Martins Teixeira
    An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

    Nathalia Luisa Sousa de Oliveira Malacco, Jessica Amanda Marques Souza ... Frederico Marianetti Soriani
    Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

    Kathryn Milne, Alasdair Ivens ... Philip J Spence
    Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima, Daisuke Kamimura ... Masaaki Murakami
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Immunology and Inflammation
    2. Medicine

    Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

    Temitayo O Idowu, Valerie Etzrodt ... Sascha David
    Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
    1. Cell Biology

    Adiponectin preserves metabolic fitness during aging

    Na Li, Shangang Zhao ... Philipp E Scherer
    Adiponectin is an essential regulator for healthspan and is indispensable for sustaining a normal lifespan.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna, Fabrice Uhel ... Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

    Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura
    The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.