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    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?

    J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Microbiology and Infectious Disease

    An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells

    Alexandra Blancke Soares, Jan Stäcker ... Tobias Spielmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Cell Biology

    A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8

    Kirill V Tarasov, Khalid Chakir ... Edward G Lakatta
    Overexpression of hAC8 engages complex, coordinate adaptation 'circuity' that has evolved in mammalian cells to defend against stress that threatens health or life, and may be important for proper healing in disease states such as heart infarction or failure.
    1. Genetics and Genomics
    2. Neuroscience

    Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

    Rachael E Barton, Lucia F Massari ... Adèle L Marston
    Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.
    1. Developmental Biology

    DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

    Maria M Mikedis, Yuting Fan ... David C Page
    DAZL promotes male fertility by enhancing the protein expression of thousands of genes to facilitate expansion and differentiation of transit-amplifying spermatogonia in the testes.
    1. Immunology and Inflammation

    Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

    Jitian He, Le Gao ... Youwei Wang
    Prdm1 (BLIMP1) promotes liver Group 1 ILCs cancer surveillance and preserves functional heterogeneity.
    1. Cell Biology
    2. Neuroscience

    Pericytes control vascular stability and auditory spiral ganglion neuron survival

    Yunpei Zhang, Lingling Neng ... Xiaorui Shi
    Pericytes in the adult ear are critical for vascular stability and spiral ganglion neuron health.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    Peng Xie, Xu Jiang ... Chengqi Lin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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