Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.
Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
Daniel J Puleston, Hanlin Zhang ... Anna Katharina Simon
Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.
Katherine A Deets, Randilea Nichols Doyle ... Russell E Vance
A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen.
Based on benchmarking various methods and analyzing multiple real scRNA-seq datasets, a computational platform/workflow and a set of tips for best practices are developed for analyzing causal interactions or relationships in single cells.
Live imaging of the duel of an NK cell versus a metastatic cancer cell on pulmonary epithelial cells reveals a novel survival tactics adopted by cancer cells.
