By attenuating the translation of key mRNA targets, ZFP36 RNA binding proteins restrain the expansion and effector activity of T cells.

Nrn1, a novel extracellular evolutionarily conserved molecule, impacts cellular electric and metabolic state and contributes to cell fate and immune response outcome.

Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.

High-throughput sequencing of the memory T cell receptor repertoire and machine learning can predict robust antibody and CD4 T cell response to de novo hepatitis B vaccine.

AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.

The co-stimulatory molecule CD28 is required after T cell priming for helper T cell polarization in response to an infection.

Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.

Autophagy is required for CD8⁺ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8⁺ T cell responses.

SARS-CoV-2 experienced ocrelizumab-treated MS patients benefit from SARS-CoV-2 mRNA vaccination by inducing broadprotective CD8+ T-cells, whereas methotrexate-treated RA patients induce delayed but strong antibody responses, which support vaccine strategies for these patient groups.

A previously unrecognized subpopulation of fibroblasts that immediately responded to stimuli from mouse periodontitis models and activated the Toll-like receptor signaling and chemokine expression to guide oral barrier immunity and gingival inflammation was revealed by mouse gingival single-cell transcriptomic atlas.