A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.
Gabriella O Estevam, Edmond Linossi ... James S Fraser
A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
Predictive pharmacology based on behavioural fingerprinting can identify druggable pathways that are altered or renormalized in zebrafish larvae that harbor mutations in early and late-onset Alzheimer's disease risk genes.
Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
Mutually exclusive splicing of two exon pairs of the only Drosophila Cav2 homolog cacophony mediates functional diversity of Cav2 channels in Drosophila.
