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Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.

Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.

Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.

Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.

Protein kinase Cδ, a kinase downstream of B-cell antigen receptor, is found to be essential for class switching to and production of IgG in the T-cell-independent type 2 immune response and for regulation of gut-residing bacteria.

Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.

Quantitative observations of single-molecule binding between antigen and T cell receptor (TCR) in living primary T cells reveals unbinding kinetics, stoichiometry and signaling molecule recruitment, providing insights into the mechanisms of antigen recognition by the immune system.

Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.

Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.

The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.