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    1. Structural Biology and Molecular Biophysics

    Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

    Geoff P O'Donoghue et al.
    Quantitative observations of single-molecule binding between antigen and T cell receptor (TCR) in living primary T cells reveals unbinding kinetics, stoichiometry and signaling molecule recruitment, providing insights into the mechanisms of antigen recognition by the immune system.
    1. Cancer Biology

    T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

    Marta Canel et al.
    Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.
    1. Immunology and Inflammation

    C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

    Chang Hoon Lee et al.
    The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.
    1. Cell Biology
    2. Immunology and Inflammation

    PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

    Graham J Britton et al.
    T cell receptor and Notch signaling pathways are linked via a novel mechanism involving modulation of the cytoskeleton.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al.
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Immunology and Inflammation

    Gamma delta T cells recognize haptens and mount a hapten-specific response

    Xun Zeng et al.
    The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
    1. Immunology and Inflammation
    2. Neuroscience

    Autoimmunity: Bringing on the itch

    Daniel A Waizman et al.
    Neutrophils are the first immune cells that enter the skin and cause itch in atopic dermatitis.
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    1. Biochemistry and Chemical Biology

    Convergent Evolution: Shaping the import system of mitochondria

    Kostas Tokatlidis
    Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their mitochondria.
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