A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
Biochemical analysis on hetero-mutated c10 subunits ring and molecular dynamics simulations demonstrate the cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation.
Jennifer L Fribourgh, Ashutosh Srivastava ... Carrie L Partch
The affinity of circadian repressors CRY1 and CRY2 for their cognate transcription factor CLOCK:BMAL1 is regulated by differential dynamics at the serine loop and interactions with the PER2 corepressor.
Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
Andrea Graziadei, Frank Gabel ... Teresa Carlomagno
Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
A consistent pattern of consumption of Triticeae tribe grasses documented in the Danube Gorges of the Balkans since the Early Mesolithic might have facilitated a quick uptake of domesticated cereals due to a developed cultural taste and specific stone tool processing technology.
Neus Martínez-Abadías, Roger Mateu Estivill ... James Sharpe
Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
Coral reef fish larval recruitment is a metamorphosis that can be disturbed by reef pollutants, as it is under the influence of the environment through the direct control of thyroid hormone signaling.
Elisabeth A Geyer, Matthew P Miller ... Luke M Rice
Antagonism between binding to unpolymerized subunits and to the lattice leads to a ratcheting model for the processive action of a microtubule polymerase.
µGUIDE is a Bayesian framework that leverages simulation-based inference to efficiently estimate posterior distributions of any forward model parameters, allowing for uncertainty quantification and degeneracy detection.