10,851 results found
    1. Structural Biology and Molecular Biophysics

    Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    Xiaomei Sun, Yuxin Ye ... Min Yao
    A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
    1. Biochemistry and Chemical Biology

    Cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation

    Noriyo Mitome, Shintaroh Kubo ... Shoji Takada
    Biochemical analysis on hetero-mutated c10 subunits ring and molecular dynamics simulations demonstrate the cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation.
    1. Biochemistry and Chemical Biology

    Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

    Jennifer L Fribourgh, Ashutosh Srivastava ... Carrie L Partch
    The affinity of circadian repressors CRY1 and CRY2 for their cognate transcription factor CLOCK:BMAL1 is regulated by differential dynamics at the serine loop and interactions with the PER2 corepressor.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd, Tyler D Wikoff ... Anna Selmecki
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The guide sRNA sequence determines the activity level of box C/D RNPs

    Andrea Graziadei, Frank Gabel ... Teresa Carlomagno
    Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
    1. Ecology
    2. Plant Biology

    Wild cereal grain consumption among Early Holocene foragers of the Balkans predates the arrival of agriculture

    Emanuela Cristiani, Anita Radini ... Dušan Borić
    A consistent pattern of consumption of Triticeae tribe grasses documented in the Danube Gorges of the Balkans since the Early Mesolithic might have facilitated a quick uptake of domesticated cereals due to a developed cultural taste and specific stone tool processing technology.
    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías, Roger Mateu Estivill ... James Sharpe
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
    1. Developmental Biology
    2. Ecology

    Fish larval recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos

    Guillaume Holzer, Marc Besson ... Vincent Laudet
    Coral reef fish larval recruitment is a metamorphosis that can be disturbed by reef pollutants, as it is under the influence of the environment through the direct control of thyroid hormone signaling.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Design principles of a microtubule polymerase

    Elisabeth A Geyer, Matthew P Miller ... Luke M Rice
    Antagonism between binding to unpolymerized subunits and to the lattice leads to a ratcheting model for the processive action of a microtubule polymerase.
    1. Neuroscience

    Introducing µGUIDE for quantitative imaging via generalized uncertainty-driven inference using deep learning

    Maëliss Jallais, Marco Palombo
    µGUIDE is a Bayesian framework that leverages simulation-based inference to efficiently estimate posterior distributions of any forward model parameters, allowing for uncertainty quantification and degeneracy detection.

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