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Flow cytometric analysis of antigen-specific B and T cell responses to heterologous immunization reveals intact dendritic cell function, but selective defects in germinal center formation, in mice with concurrent malaria.

Genetic ablation of Raptor and Rictor in mice revealed critical roles of mTORC1 and mTORC2 in T follicular helper cell differentiation and germinal center responses.

In the setting of CNS infection, meningeal lymphatic drainage promotes dendritic cell and T cell responses in the deep cervical lymph nodes but is not necessary for maintaining control of parasite in the brain.

Digitalized TCR repertoire-based view on antigenic specificity, plasticity, and tissue residence of regulatory T cells.

Clonotypic tracing of SARS-CoV-2–responsive T cells reveals vaccination-induced dominant Tfh clonotypes, not pre-existing T cells, associated with sustained humoral response, and can serve as an index of antigen-specific antibody longevity.

Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.

Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.

Chronic exposure to a potent chemical contact sensitizer drives a self-limiting expansion of a polyclonal population of T cells recognizing a small number of dominant antigens.

Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.

Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.