14,682 results found
    1. Genetics and Genomics

    RNA-programmed genome editing in human cells

    Martin Jinek, Alexandra East ... Jennifer Doudna
    A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.
    1. Developmental Biology
    2. Neuroscience

    Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

    Youngshik Choe, Trung Huynh, Samuel J Pleasure
    During development the Sonic Hedgehog protein is produced by epithelial structures and acts at a distance in the brain and perhaps in other organs.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection

    Balaji Banoth, Budhaditya Chatterjee ... Soumen Basak
    The integration of signals via the pleiotropic NF-kappaB (NF-κB) system enables microenvironmental cues to tune cellular responses to pathogenic substances.
    1. Cell Biology

    Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

    Susumu Hirabayashi, Ross L Cagan
    The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
    1. Physics of Living Systems

    Rheotaxis facilitates upstream navigation of mammalian sperm cells

    Vasily Kantsler, Jörn Dunkel ... Raymond E Goldstein
    Mammalian sperm subject to shear flow swim in upstream spirals along the walls bounding such flows, thereby demonstrating a robust mechanism for upstream navigation to the ovum.
    1. Epidemiology and Global Health

    Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy

    Silvia de Sanjosé, Rebecca B Perkins ... Mark Schiffman
    The PAVE strategy aims to provide a cost-effective, high quality ‘Screen-Triage-Treat’ approach for cervical cancer screening to save many lives.
    1. Computational and Systems Biology
    2. Medicine

    Early stage NSCLS patients’ prognostic prediction with multi-information using transformer and graph neural network model

    Jie Lian, Jiajun Deng ... Varut Vardhanabhuti
    It provides evidence for the feasibility of using combined graph convolutional neural network and transformers’ based systems with patient demographics, and CT-derived imaging features as inputs into the transformer model for survival prediction in early stage lung cancer patients.
    1. Physics of Living Systems

    Large-scale orientational order in bacterial colonies during inward growth

    Mustafa Basaran, Y Ilker Yaman ... Askin Kocabas
    When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic, Yoon-Mi Hur ... Karri Silventoinen
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa, Robert C Froemke ... Mark CW van Rossum
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.

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