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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

    Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
    Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
    1. Immunology and Inflammation

    AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

    Edward T Schmid, Iris K Pang ... Carla V Rothlin
    AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.
    1. Ecology
    2. Microbiology and Infectious Disease

    Freshwater monitoring by nanopore sequencing

    Lara Urban, Andre Holzer ... Maximilian R Stammnitz
    From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

    Basel Maher Al-Barghouthi, Will T Rosenow ... Charles R Farber
    Systems genetics approaches identify potentially causal bone mineral density genes.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer, Lee A Albacker ... Peter K Sorger
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity

    Chen Qiu, Vandita D Bhat ... Traci M Tanaka Hall
    A Caenorhabitis elegans RNA-binding protein, FBF-2, modulates RNA sequence motif recognition through conformational change and partner protein interaction.
    1. Neuroscience

    Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells

    Marina Garrett, Sahar Manavi ... Shawn R Olsen
    VIP inhibitory neurons are active in response to novel images but are suppressed by familiar stimuli and show ramping activity when expected stimuli are omitted.
    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann, Maximilian Nguyen ... Andreas Mayer
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang, Shan Zhong ... Joseph R Ecker
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Ecology

    Testosterone pulses paired with a location induce a place preference to the nest of a monogamous mouse under field conditions

    Radmila Petric, Matina Kalcounis-Rueppell, Catherine A Marler
    Transient increases in the hormone testosterone shift behavioral focus by influencing both spatial preference and vocalizations of a monogamous and biparental mouse in the wild.