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By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.

KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.

Amino acid limitation triggers preferential uncharging of glutamine-specific tRNAs and depletes polyglutamine tract-containing proteins from mammalian cells, revealing a potential role for polyglutamine tracts as sensors of glutamine sufficiency.

Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.

Electrical synapses determine the precise position of chemical synapses in the nervous system.

Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.

The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.

The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.

During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.

Analysis of the mechanism of action of cystic fibrosis corrector drugs reveals signalling pathways potently controlling the proteostasis of the main disease-relevant CFTR mutant.