2,547 results found
    1. Structural Biology and Molecular Biophysics

    Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand

    Jiacheng Zhang et al.
    The glycine T-box riboswitch recognizes tRNAgly and senses its aminoacylation state by first interacting with the anticodon region and subsequently probing the 3' end of the ligand using both specific structural elements and conformational dynamics.
    1. Developmental Biology
    2. Human Biology and Medicine

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe et al.
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities

    Kamesh Narasimhan et al.
    Protein binding microarrays highlight the diversification of DNA-binding motifs for the nuclear hormone receptor and C2H2 zinc finger transcription factor families, and reveal unexpected diversity in motifs for the T-box and DM families.
    1. Cell Biology
    2. Developmental Biology

    Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

    Pavan Kumar P et al.
    A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Distinct responses to reduplicated chromosomes require distinct Mad2 responses

    Benjamin M Stormo, Donald T Fox
    Mitosis of reduplicated chromosomes is under careful regulation and can be perfectly executed.
    1. Developmental Biology

    Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity

    Benjamin Schwarz et al.
    A novel regulatory model for the diversification of cardiac cell subpopulations in Drosophila is established by linking epidermal growth factor signaling with differential activities of key transcription factors.
    1. Developmental Biology

    Hox genes control vertebrate body elongation by collinear Wnt repression

    Nicolas Denans et al.
    The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.
    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of Segmentation: Sox enters the picture

    Felix Kaufholz, Natascha Turetzek
    The discovery of a gene that regulates two segmentation mechanisms in spider embryos is fueling the ongoing debate about the evolution of this crucial developmental process.
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